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Failure of spermatogonia to undergo differentiation in humans results in a neoplastic transformation into carcinoma in situ leading to a testicular germ cell carcinoma in the adult blood pressure medication how long to take effect cheap exforge 80mg buy line. The secondary spermatocytes rapidly undergo the second meiotic division (or equational division). Because the first meiotic division is a long process (days) and the second meiotic division is very short (minutes), primary spermatocytes are the most abundant cells observed in the seminiferous epithelium. The first meiotic division is characterized by a long prophase, lasting about 10 days. The formation of a synaptonemal complex (see Box 20-C) during zygotene-pachytene to facilitate the pairing or synapsis of homologous chromosomes (autosomes and sex chromosomes X and Y). Meiosis in the female First polar body 4C Second polar body Primary oocyte (at diplotene, prophase of meiosis I, at the time of birth) 2C In the female: 1. The proliferation by mitosis of oogonia, equivalent to spermatogonia in the male, occurs in the fetal ovary. Prophase of the first meiotic division also starts in the fetal ovary and is arrested at diplotene. Completion of the first meiotic division, resulting in the formation of the first polar body and a secondary oocyte, occurs at ovulation. Completion of the second meiotic division, yielding a haploid egg and a second polar body, takes place at fertilization. A zygote is formed when two haploid cells, sperm and egg, combine their genetic material at fertilization. Fertilizing sperm Zona pellucida Secondary oocyte Meiosis I is completed at ovulation. First meiotic division (prophase stage): From leptotene to zygotene to pachytene A Leptotene B Zygotene Each homologous chromosome consists of two sister chromatids. Homologous chromosomes Nonsister chromatids Synapsis of homologous chromosomes starts. Starting from nuclear envelope attachment points, a synaptonemal complex develops between the homologous chromosomes. Crossing over is the exchange of genetic information between non-sister chromatids of homologous chromosomes. Crossovers foster genetic diversity and establish physical links between homologues to ensure precise segregation. Crossovers along any given chromosome pair are evenly spaced over distances from 300 nm to 30 m. Crossover interference means that crossover at a given chromosomal site prevents another crossover to occur too close to it. Disjunction (the separation of paired homologous chromosomes) after completion of crossover. After this prolonged prophase, pairs of sister chromatids pass through metaphase, anaphase, and telophase and are separated into daughter cells, the secondary spermatocytes. During the second meiotic division, prophase, metaphase, anaphase, and telophase separate sister chromatids into daughter cells, the spermatids.

Syndromes

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Implantation of the fertilized egg depends on a hormonally primed endometrium (see Chapter 23 blood pressure 300180 cheap exforge 80mg mastercard, Fertilization, Placentation, and Lactation) consisting of secretory endometrial glands surrounded by decidual cells. Ciliated cells, which enlarge and produce cilia (ciliogenesis) as folliculogenesis and estrogen production is in progress. Nonciliated secretory cells (called peg cells), whose secretory activity is also stimulated by estrogens. The peristaltic contraction of the muscular wall, with an inner circular-spiral layer and an outer longitudinal layer, as well as the ciliary activity of the lining epithelial cells, propel the oocyte or fertilized egg/embryo toward the uterus. The major component of the wall is the myometrium, lined by a mucosa, the endometrium. The central layer is thick with circularly arranged muscle fibers and abundant blood vessels, which give the name stratum vasculare to this particular layer. The outer and inner layers contain longitudinally or obliquely arranged muscle fibers. Decidual cell Decidual cells Decidual cells derive from the epithelial-like transformation of endometrial stroma cells (decidual reaction in preparation for embryo implantation). Together with trophoblast cells, decidual cells prevent the immunologic rejection of genetically different embryonic and fetal tissues. Decidual cells have an endocrine role: the production of decidual prolactin, related to pituitary prolactin, with a trophic effect on the corpus luteum. Recruitment of inflammatory cells Lymphocytes, macrophages, and eosinophils are attracted to the implantation site. Corpus luteum Progesterone Lymphocyte Decidual cells Eosinophil In addition to decidual prolactin, decidual cells produce prostaglandins and relaxin. During pregnancy, myometrial smooth muscle enlarges (hypertrophy) and the fibers increase in number (hyperplasia). Inhibition of myometrial contraction during pregnancy is controlled by relaxin, a peptide hormone produced in the ovary and placenta. The endometrium consists of a simple columnar epithelial lining, associated with simple tubular endometrial glands, and the lamina propria, called the endometrial stroma. A basal layer, retained as the source of regeneraDecidual cell tion of a new functional layer following menstruation. The proliferative phase (also called the estrogenic or follicular phase) is of about 9 days duration. After day 14, when ovulation occurs, the endometrium begins its secretory or progestational phase, which lasts approximately 13 days. During this phase, the endometrium has a thickness of 5 to 7 mm and endometrial glands initiate their secretory activity. Blood vessels parallel to the endometrial glands increase in length and the lamina propria contains excessive fluid (edema).

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Essential concepts Follicle Development and the Menstrual Cycle · Development of the female genital ducts heart attack 720p download cheap exforge 80mg buy. The caudal segments fuse to develop into the uterovaginal primordium, which becomes the uterus and upper part of the vagina. The canalization of the vaginal plate (the contact point of the uterovaginal primordium with the urogenital sinus) results in the middle and lower parts of the vagina. The genital tubercle (phallus) develops at the cranial end of the cloacal membrane. The labioscrotal swellings (that will give rise to the labia majora) and urogenital folds (that will give rise to the labia minora) develop at either side of the cloacal membrane. Müllerian agenesis is characterized by the absence of the uterus, cervix, and upper vagina. Primary sex cords, derived from the coelomic epithelium, are replaced by secondary sex cords surrounding oogonia. Oogonia are mitotically dividing cells derived from primordial germ cells with two X chromosomes. Therefore, at the time of birth, primary oocytes at the diplotene stage of Meiosis I are surrounded by granulosa cells. Physical findings recognized in prepubertal and pubertal girls include congenital lymphedema, short stature, and gonadal dysgenesis. The cortex houses the primordial follicles; the medulla is connected to the hilum consisting of blood vessels (ovarian artery and vein), nerves, and lymphatic vessels. The ovarian cycle comprises three phases: (1) Follicular phase, consisting of the development of a primordial follicle into a preovulatory, antral or graafian follicle. The follicular phase (or folliculogenesis) results in the following sequence: (1) Primordial follicle: a primary oocyte is surrounded by a single layer of flattened squamous granulosa cells supported by a basal lamina. Cell processes of the granulosa cells adjacent to the zona pellucida (the future corona radiata) penetrate the thickened zona pellucida and establish contact with the plasma membrane of the primary oocyte. Reciprocal molecular cooperation occurs between the primary oocyte and granulosa cells. Gap junctions are present at the contact points and between adjacent granulosa cells. In addition, spaces containing fluid (liquor folliculi; also named Call-Exner bodies) appear between the multilayered granulosa cells. Stromal cells surrounding the developing follicle differentiate into two layers: the highly vascularized theca interna, producing androstenedione that is transferred to granulosa cells across the basal lamina so they can produce estrogen.

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Customer Reviews

Ramon, 46 years: Agents that prevent microtubular function -tubulin -tubulin Colchicine binding to tubulin dimers prevents their assembly into microtubules.

Cronos, 60 years: Sympathetic nerve Parasympathetic nerve the connective tissue septum limits a pulmonary lobule Bronchial artery Pulmonary vein plexuses Pulmonary vein plexuses drain the alveolar capillaries Bronchial arteries, carrying oxygenated blood, also follow the bronchial tree and supply branches to the walls of the bronchi, arteries, veins, and connective tissue septa.

Kippler, 35 years: These assemble into new virus particles, which are then released from the host cell.

Gancka, 55 years: Imagine that you can visualize a wave by "traveling" along the length of a seminiferous tubule.